Anyone who had the privilege to know Marty Mihm appreciated his warm and dynamic personality and wealth of knowledge. He was an inspiration to many and had an energy and spirit that was profound. He served as Chief of the Massachusetts General Hospital Dermatopathology Unit Director of the Melanoma Program in Dermatology at the Brigham and Women's Hospital and Dana-Farber and Brigham and Women's Cancer Center, however, this cannot overshadow his contributions in Vascular Anomalies. While most of his (>400!) publications were in the field of melanoma, Marty, an ISSVA member, provided great insights into the pathophysiology of vascular lesions and co-authored many seminal papers in the field of vascular anomalies, as listed below.
Reading the tributes in his obituary reveals the impact he had on numerous trainees, friends, and colleagues.
Marty played an active role in patient advocacy groups (eg the Vascular Birthmark Foundation - VBF), helped establish vascular anomalies centers in Vietnam and other countries, and continued to participate in international meetings until a few years ago.
There will be a VBF-initiated Martin C. Mihm Physician Education Grant to support a pathology trainee for a 40 hour training session, which will be taught by Dr. Paula North.
The ISSVA community has lost an accomplished and dear friend.
Histopathology of vascular anomalies.
Aboutalebi A, Jessup CJ, North PE, Mihm MC Jr.Facial Plast Surg. 2012 Dec;28(6):545-53
Current theories on the pathogenesis of infantile hemangioma.
Lo K, Mihm M, Fay A.Semin Ophthalmol. 2009 May-Jun;24(3):172-7
Current knowledge of the pathogenesis of infantile hemangiomas.
Phung TL, Hochman M, Mihm MC.Arch Facial Plast Surg. 2005 Sep-Oct;7(5):319-21
Vascular tumors of infancy and childhood: beyond capillary hemangioma.
North PE, Waner M, Buckmiller L, James CA, Mihm MC Jr.Cardiovasc Pathol. 2006 Nov-Dec;15(6):303-17
The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.
Nguyen V, Hochman M, Mihm MC Jr, Nelson JS, Tan W.Int J Mol Sci. 2019 May 7;20(9):2243
Prox-1 promotes invasion of kaposiform hemangioendotheliomas.
Dadras SS, Skrzypek A, Nguyen L, Shin JW, Schulz MM, Arbiser J, Mihm MC, Detmar M.J Invest Dermatol. 2008 Dec;128(12):2798-806
The somatic GNAQ mutation (R183Q) is primarily located within the blood vessels of port wine stains.
Tan W, Nadora DM, Gao L, Wang G, Mihm MC Jr, Nelson JS.J Am Acad Dermatol. 2016 Feb;74(2):380-3
The nonrandom distribution of facial hemangiomas.
Waner M, North PE, Scherer KA, Frieden IJ, Waner A, Mihm MC Jr.Arch Dermatol. 2003 Jul;139(7):869-75
Facial nerve hemangiomas: vascular tumors or malformations?
Benoit MM, North PE, McKenna MJ, Mihm MC, Johnson MM, Cunningham MJ.Otolaryngol Head Neck Surg. 2010 Jan;142(1):108-14
Topical rapamycin systematically suppresses the early stages of pulsed dye laser-induced angiogenesis pathways.
Gao L, Phan S, Nadora DM, Chernova M, Sun V, Preciado SM, Ballew B, Jia Z, Jia W, Wang G, Mihm MC Jr, Nelson JS, Tan W.Lasers Surg Med. 2014 Nov;46(9):679-88
Differential expression of SKI oncogene protein in hemangiomas.
O TM, Tan M, Tarango M, Fink L, Mihm M, Ma Y, Waner M.Otolaryngol Head Neck Surg. 2009 Aug;141(2):213-8
Novel genetic mutations in a sporadic port-wine stain.
Lian CG, Sholl LM, Zakka LR, O TM, Liu C, Xu S, Stanek E, Garcia E, Jia Y, MacConaill LE, Murphy GF, Waner M, Mihm MC Jr.JAMA Dermatol. 2014 Dec;150(12):1336-40
Sustained activation of c-Jun N-terminal and extracellular signal-regulated kinases in port-wine stain blood vessels.
Tan W, Chernova M, Gao L, Sun V, Liu H, Jia W, Langer S, Wang G, Mihm MC Jr, Nelson JS.J Am Acad Dermatol. 2014 Nov;71(5):964-8
Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma.
Le Huu AR, Jokinen CH, Rubin BP, Mihm MC, Weiss SW, North PE, Dadras SS.Am J Surg Pathol. 2010 Nov;34(11):1563-73
Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks.
Phung TL, Oble DA, Jia W, Benjamin LE, Mihm MC Jr, Nelson JS.
Infantile hemangiomas are arrested in an early developmental vascular differentiation state.
Dadras SS, North PE, Bertoncini J, Mihm MC, Detmar M.Mod Pathol. 2004 Sep;17(9):1068-79
Topical rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of photocoagulated cutaneous blood vessels.
Tan W, Jia W, Sun V, Mihm MC Jr, Nelson JS.Lasers Surg Med. 2012 Dec;44(10):796-804
Photodynamic therapy for cutaneous proliferative vascular tumors in a mouse model.
Middelkamp-Hup MA, Sánchez-Carpintero I, Kossodo S, Waterman P, González S, Mihm MC Jr, Anderson RR.J Invest Dermatol. 2003 Sep;121(3):634-9
Observations on enhanced port wine stain blanching induced by combined pulsed dye laser and rapamycin administration.
Nelson JS, Jia W, Phung TL, Mihm MC Jr.Lasers Surg Med. 2011 Dec;43(10):939-42.
Infantile hemangioma: clinical resolution with 5% imiquimod cream.
Martinez MI, Sanchez-Carpintero I, North PE, Mihm MC Jr.Arch Dermatol. 2002 Jul;138(7):881-4; discussion 884.
Stem cell marker upregulation in normal cutaneous vessels following pulsed-dye laser exposure and its abrogation by concurrent rapamycin administration: implications for treatment of port-wine stain birthmarks.
Loewe R, Oble DA, Valero T, Zukerberg L, Mihm MC Jr, Nelson JS.J Cutan Pathol. 2010 Apr;37 Suppl 1(Suppl 1):76-82.
Pilot study examining the combined use of pulsed dye laser and topical Imiquimod versus laser alone for treatment of port wine stain birthmarks.
Chang CJ, Hsiao YC, Mihm MC Jr, Nelson JS.Lasers Surg Med. 2008 Nov;40(9):605-10.
Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment.
Jia W, Sun V, Tran N, Choi B, Liu SW, Mihm MC Jr, Phung TL, Nelson JS.Lasers Surg Med. 2010 Feb;42(2):105-12.
Congenital nonprogressive hemangioma: a distinct clinicopathologic entity unlike infantile hemangioma.
North PE, Waner M, James CA, Mizeracki A, Frieden IJ, Mihm MC Jr.Arch Dermatol. 2001 Dec;137(12):1607-20.
A unique microvascular phenotype shared by juvenile hemangiomas and human placenta.
North PE, Waner M, Mizeracki A, Mrak RE, Nicholas R, Kincannon J, Suen JY, Mihm MC Jr.Arch Dermatol. 2001 May;137(5):559-70.
GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas.
North PE, Waner M, Mizeracki A, Mihm, MC Hum Pathol 2000;31:11-22.